Number of germ-line cell divisions per generation in female

Value 23 divisions/generation
Organism Human Homo sapiens
Reference Crow JF. The origins, patterns and implications of human spontaneous mutation. Nat Rev Genet. 2000 Oct1(1):40-7. p. 41 right column, 3rd paragraphPubMed ID11262873
Primary Source 1) Drost JB, Lee WR. Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen. 1995 25 Suppl 26:48-64. AND (2) Vogel, F. & Motulsky, A. G. Human Genetics Problems and Approaches. (Springer, Berlin,1997).PubMed ID7789362
Method "In the female there are 22 cell divisions before meiosis and two during meiosis, giving 23 chromosome replications in total, because only one replication occurs during the two meiotic divisions. As all the cell divisions are completed before birth, there is no increase with postnatal age."
Comments Note: Ref gives value of 23 divisions/generation citing primary source 2 and in p. 42 fig 2 adapted from it. Primary source 1 however write that the estimates of the number of germ cell divisions per generation are: for humans, 401 (30-year generation) in males and 31 in females. See in primary source 1 figure 6 p.55 figure - link
Entered by Uri M
ID 105585