Fraction of DNA that is transcribed

Value 85.2 %
Organism Human Homo sapiens
Reference Hangauer MJ, Vaughn IW, McManus MT. Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet. 2013 Jun9(6):e1003569. doi: 10.1371/journal.pgen.1003569 p.2 left column top paragraph, right column top paragraph and p.3 caption to figure 1 (A)PubMed ID23818866
Method P.2 right column top paragraph: "At a threshold of one RNA-seq read, [investigators] observed reads mapping to 78.9% of the genome and, if additional evidence of transcription is taken into account including the full structures of known genes, spliced ESTs [expressed sequence tags] and cDNAs [complementary DNAs], [they] found evidence that 85.2% of the genome is transcribed (Figure 1A). This result closely agrees with the recently published findings from the ENCODE project in which evidence for transcription of 83.7% of the genome was uncovered [BNID 115144 ref 14]."
Comments P.2 left column top paragraph: "Here, by analyzing a large set of RNA-seq data, [investigators] found that >85% of the genome is transcribed, allowing [them] to generate a comprehensive catalog of an important class of intergenic transcripts: long intergenic noncoding RNAs (lincRNAs)." P.3 caption to figure 1 (A): "85.2% of the genome has evidence of transcription, with RNA-seq reads mapping directly to 78.9% of genomic sequence. The remaining genomic coverage is comprised of known genes, spliced ESTs and spliced cDNAs. The grey circle represents the portion of the genome (83.4%) that is uniquely mappable with RNA-seq reads."
Entered by Uri M
ID 115145