fraction of intergenic DNA in bacteria <5%: fraction of coding DNA in multicellular species <5% %
||Michael Lynch and Georgi K. Marinov, The bioenergetic costs of a gene, PNAS 2015 doi: 10.1073/pnas.1514974112 p.3 left column top paragraph
|| Lynch M (2006) Streamlining and simplification of microbial genome architecture. Annu Rev Microbiol 60: 327 – 349  Lynch M, Bobay LM, Catania F, Gout JF, Rho M (2011) The repatterning of eukaryotic genomes by random genetic drift. Annu Rev Genomics Hum Genet 12: 347 – 366. doi: 10.1146/annurev-genom-082410-101412.PubMed ID16824010, 21756106
||P.3 left column top paragraph:"These results provide a quantitative basis for understanding the evolutionary maintenance of highly streamlined bacterial genomes, which typically have <5% intergenic DNA and generally few (if any) introns or mobile elements (primary source 15), in contrast to the bloated genomes of multicellular species, which typically contain <5% coding DNA and harbor massive numbers of large introns and mobile elements (primary source 16)."