Frequency of arisal of "persister cells"

Range ~1.2e-6 "persister cells"/ordinary cells
Organism Bacteria Escherichia coli
Reference Stewart EJ, Madden R, Paul G, Taddei F. Aging and death in an organism that reproduces by morphologically symmetric division. PLoS Biol. 2005 Feb3(2):e45. p.0298 right column top paragraphPubMed ID15685293
Primary Source Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. Bacterial persistence as a phenotypic switch. Science. 2004 Sep 10 305(5690):1622-5.PubMed ID15308767
Method P.0296 left column top paragraph: "To determine if E. coli experiences aging related to the inheritance of the old pole, [investigators] followed individual exponentially growing cells in an automated fluorescence microscopy system through up to nine generations of growth and reproduction, measuring the physical parameters of each cell over time."
Comments P.0298 right column top paragraph: "This observation is consistent with the hypothesis that aged cells are more susceptible to harmful events and/or less likely to survive them. It is unlikely that these cells represent a growth arrested “persister” state, as it has recently been demonstrated that persister cells that arise during exponential growth occur at a frequency of approximately 1.2×10^-6 [primary source]: the appearance of apparently dead cells in [investigators'] study (about 4.6×10^-4) is almost 400 times more frequent."
Entered by Uri M
ID 111487