| Range |
~1.2e-6 "persister cells"/ordinary cells
|
| Organism |
Bacteria Escherichia coli |
| Reference |
Stewart EJ, Madden R, Paul G, Taddei F. Aging and death in an organism that reproduces by morphologically symmetric division. PLoS Biol. 2005 Feb3(2):e45. p.0298 right column top paragraphPubMed ID15685293
|
| Primary Source |
Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S. Bacterial persistence as a phenotypic switch. Science. 2004 Sep 10 305(5690):1622-5.PubMed ID15308767
|
| Method |
P.0296 left column top paragraph: "To determine if E. coli experiences aging related to the inheritance of the old pole, [investigators] followed individual exponentially growing cells in an automated fluorescence microscopy system through up to nine generations of growth and reproduction, measuring the physical parameters of each cell over time." |
| Comments |
P.0298 right column top paragraph: "This observation is consistent with the hypothesis that aged cells are more susceptible to harmful events and/or less likely to survive them. It is unlikely that these cells represent a growth arrested “persister” state, as it has recently been demonstrated that persister cells that arise during exponential growth occur at a frequency of approximately 1.2×10^-6 [primary source]: the appearance of apparently dead cells in [investigators'] study (about 4.6×10^-4) is almost 400 times more frequent." |
| Entered by |
Uri M |
| ID |
111487 |