Volume of typical presynaptic varicosity

Range ~1 fL
Organism Rat Rattus norvegicus
Reference Rangaraju V, Calloway N, Ryan TA. Activity-driven local ATP synthesis is required for synaptic function. Cell. 2014 Feb 13 156(4):825-35. doi: 10.1016/j.cell.2013.12.042. p.827 left columnPubMed ID24529383
Comments "These data show that under [researchers'] standard recording conditions <ATP(presyn)> = 1.4 mM ( Figure 2 A, absence of TTX [Tetrodotoxin]) (averaged over 150 neurons, each providing 20–30 boutons, CV = 29%) which corresponds to ~10^6 molecules in a typical presynaptic varicosity (~1fl). "
Entered by Uri M
ID 111086