| Range |
~10^8 molecules IgG, IgA or IgM/cell/h
|
| Organism |
Human Homo sapiens |
| Reference |
Hibi T, Dosch HM. Limiting dilution analysis of the B cell compartment in human bone marrow. Eur J Immunol. 1986 Feb16(2):139-45. p.139 right column top paragraphPubMed ID2869953
|
| Method |
"[Researchers] used limiting dilution
(LD)
analysis
to
characterize
BM
Ig secretors." |
| Comments |
"[Researchers'] results suggest that
2 populations
of
Ig
producing
BM
B
lineage
cells
can
be
distinguished
from
a
large, third
population
of
B
cells
unable
to
secrete
Ig
under
[Researchers']
culture conditions.
The
first
population
contains
cells
producing Ig “spontaneously”
in
unstimulated
cultures.
It
is
small
but
has
very
high
secretory rates
of
approximately
10^8
molecules
IgG,
IgA
or
IgM/cell/h.
If
these
cells
produced
their
antibody
at
similar
rates
in
vivo,
then their
frequencies
would suggest
that
they
could
provide up
to
2/3
of
daily
synthetic
rates for
IgG
and
IgA
and
20-30%
of
the
daily
whole
body
IgM
production. These
cells
are
nonproliferating
and
cannot
be
infected, activated
nor
transformed
with
Epstein-Barr
virus
(EBV)." BM=bone marrow |
| Entered by |
Uri M |
| ID |
110223 |