Proteasomes in malignant human hematopoietic cells and normal blood mononuclear cells

Range Table - link ng/mg cell protein
Organism Human Homo sapiens
Reference Kumatori A et al., Abnormally high expression of proteasomes in human leukemic cells. Proc Natl Acad Sci U S A. 1990 Sep87(18):7071-5. p.7073 table 1PubMed ID2205851
Method See notes beneath table
Comments P.7073 left column 2nd paragraph: "Proteasome Levels in Malignant Hematopoietic Cells. [Investigators] next examined the expression of proteasomes in various types of malignant hematopoietic cell lines by quantitative enzyme immunoassay (Table 1) For some unknown reason, the proteasome contents of normal mononuclear cells were much lower than those of cells in normal tissues of rats (ref 15) and humans (unpublished data)." P.7074 left column bottom paragraph: "Proteasomes presumably play an essential role in crucial cellular activities, because they are ubiquitous in eukaryotic cells (refs 1, 15, 16). In the present study, [investigators] found that expression of proteasomes was abnormally high in malignant human hematopoietic cell lines and growth-stimulated mononuclear cells (Table 1 and Fig. 6)."
Entered by Uri M
ID 108041