Calculated total translation time of the lacZ gene (1025 codons)

Value 82 sec Range: ±0.6 sec
Organism Bacteria Escherichia coli
Reference Solomovici J, Lesnik T, Reiss C. Does Escherichia coli optimize the economics of the translation process? J Theor Biol. 1997 Apr 21 185(4):511-21PubMed ID9156078
Primary Source Sørensen MA, Kurland CG, Pedersen S. Codon usage determines translation rate in Escherichia coli. J Mol Biol. 1989 May 20 207(2):365-77.PubMed ID2474074
Method Primary source: In order to determine the difference in translation rate between different codons, researchers inserted a small DNA fragment in the lacZ gene either directly or flanked by a few frame-shifting bases, leaving the reading frame of the lacZ gene unchanged.
Comments Under standard growth conditions. Average translation rate of 12.5 aa/sec
Entered by Uri M
ID 104870