Fraction of genes that are bidirectionally transcribed

Value >= % Range: >70 %
Organism Mammals
Reference Carninci P, Yasuda J, Hayashizaki Y. Multifaceted mammalian transcriptome. Curr Opin Cell Biol. 2008 Jun20(3):274-80. p.276 right column 2nd paragraphPubMed ID18468878
Primary Source Katayama S et al. FANTOM Consortium. Antisense transcription in the mammalian transcriptome. Science. 2005 Sep 2 309(5740):1564-6PubMed ID16141073
Comments Antisense transcription (transcription from the opposite strand to a protein-coding or sense strand) has been ascribed roles in gene regulation involving degradation of the corresponding sense transcripts (RNA interference), as well as gene silencing at the chromatin level. "Although the number of reports is still limited, it is probable that transcriptional interference will be broadly investigated as we now understand that more than 70% of genes are subjected to bidirectional transcription [primary source]."
Entered by Uri M
ID 103747