Energy content in distinct patches of contact between DNA and histones

Value 3.6 kcal/mol
Organism Eukaryotes
Reference Garcia HG, Grayson P, Han L, Inamdar M, Kondev J, Nelson PC, Phillips R, Widom J, Wiggins PA. Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers. 2007 Feb 5 85(2):115-30.PubMed ID17103419
Comments The interactions between protein and DNA within the nucleosome core particle can be divided into seven unique DNA-binding sites per half-particle, corresponding to the regions where the minor groove of the double helix faces inward (fig. 1b). These contacts between the protein core of the nucleosome and the wrapped DNA occur in patches, every DNA helical turn, when the minor groove (DNA backbone) wraps around and faces inward toward the protein core. For value of ~1kcal/mole see BNID 105961
Entered by Uri M
ID 103143