Number of genes

Range ≈4,100 genes
Organism Bacteria Bacillus subtilis
Reference Kobayashi K et al., Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A. 2003 Apr 15 100(8):4678-83. abstract, p.4679 left column bottom paragraph & p.4683 left column 2nd paragraphPubMed ID1268229
Method "To obtain an independent and possibly more reliable estimate of a minimal protein-encoding gene set for bacteria, [researchers] systematically inactivated Bacillus subtilis genes."
Comments "There are ˜4,100 annotated genes in the B. subtilis genome (ref 9 PMID 9384377). Some 303 are encoded on prophages that can be eliminated from the genome and are not essential. Previous studies on 656 B. subtilis genes identified 42 that are essential (Table 1)." "Over 80% of essential B. subtilis gene homologues are present in all bacteria with genomes above ˜3 Mb, and 57% are found even in bacteria with the smallest genomes (mycoplasma). Almost 70% of genes are present in at least one kingdom other than Bacteria. Many organisms thus appear to rely on a similar set of essential functions, supporting the simple microbial cell view outlined above."
Entered by Ron Milo - Admin
ID 100526