Fraction of genome accounted for by Alu sequences (roughly 300 bp long each)

Range ~10 %
Organism Human Homo sapiens
Reference Bazak L et al., A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes. Genome Res. 2014 Mar24(3):365-76. doi: 10.1101/gr.164749.113. p.365 right column 2nd paragraphPubMed ID24347612
Comments p.365 right column 2nd paragraph:"The primate specific Alu sequences are the dominant short interspersed nuclear element (SINEs) in the primate genomes (International Human Genome Sequencing Consortium 2001 Cordaux and Batzer 2009). Humans have about a million copies of Alu, roughly 300 bp long each, accounting for ~10% of their genome. Since these repeats are so common, especially in gene-rich regions (Korenberg and Rykowski 1988), pairing of two oppositely oriented Alus located in the same pre-mRNA structure is likely. Such pairing produces a long and stable dsRNA structure, an ideal target for the ADARs [adenosine deaminases acting on RNA]. Indeed, recent studies have shown that Alu repeats account for >99% of editing events found so far in humans (Athanasiadis et al. 2004 Blow et al. 2004 Kim et al. 2004 Levanon et al. 2004 Ramaswami et al. 2012, 2013)."
Entered by Uri M
ID 111915