Actin treadmilling rate (subunits per pointed end per second)

Range in cells ~20: in vitro 0.1 sec^-1
Organism Unspecified
Reference Bernstein BW, Bamburg JR. Actin-ATP hydrolysis is a major energy drain for neurons. J Neurosci. 2003 Jan 1 23(1):1-6. p.4 right column bottom paragraphPubMed ID12514193
Primary Source Zigmond SH (1993) Recent quantitative studies of actin filament turnover during cell locomotion. Cell Motil Cytoskel 25: 309–316. & Didry D, Carlier MF, PantaloniD (1998) Synergy between actin depolymerizing factor/cofilin and profilin in increasing actin filament turnover. J Biol Chem 273: 25602–25611.PubMed ID8402952, 9748225
Comments "The actin treadmilling rate in cells is ~20 sec^-1, assuming that it is 200 times faster than the in vitro rate of 0.1 sec^-1 (1st primary source), i.e., there is a release of 20 subunits per pointed end per second (2nd primary source)."
Entered by Uri M
ID 110643