Lifespan of osteoclasts

Range ~2 Table - link weeks
Organism Human Homo sapiens
Reference Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000 Apr21(2):115-37. p.116 table 1 and p.122 right column bottom paragraphPubMed ID10782361
Primary Source (Source of table:) Parfitt AM 1994 Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 55 :273–286PubMed ID7962158
Comments "The average lifespan of human osteoclasts is about 2 weeks, while the average lifespan of osteoblasts is 3 months (Table 1). After osteoclasts have eroded to a particular distance, either from the central axis in cortical bone or to a particular depth from the surface in cancellous bone, they die and are quickly removed by phagocytes (ref 139). The majority (65%) of the osteoblasts that originally assembled at the remodeling site also die (ref 140)."
Entered by Uri M
ID 109906