Unitary conductance of "excitability-inducing material" (EIM) channel in 0.1 M KCl

Value 400 pS
Organism Unspecified
Reference Latorre R, Miller C. Conduction and selectivity in potassium channels. J Membr Biol. 1983 71(1-2):11-30. p.12 left column 3rd paragraphPubMed ID6300405
Primary Source Latorre R, Ehrenstein G, Lecar H. Ion transport through excitability-inducing material (EIM) channels in lipid bilayer membranes. J Gen Physiol. 1972 Jul60(1):72-85.PubMed ID5042024
Comments "Increased selectivity requires an enhanced intimacy of the channel's interaction with the transported ions, an intimacy which in turn would seem to imply hindered diffusion for all ions. For example, Latorre et al. [primary source] established that the EIM channel has a very high unitary conductance (400 pS in 0.1 M KCl) and that the alkali metal cations permeate "nonselectively," in proportion to their free-solution mobilities."
Entered by Uri M
ID 109165