Losses of translational plus rotational entropy expected for many bimolecular reactions in solution
|40 to 50 Entropy units
|Page MI, Jencks WP. Entropic contributions to rate accelerations in enzymic and intramolecular reactions and the chelate effect. Proc Natl Acad Sci U S A. 1971 Aug68(8):1678-83. p.1679 right column bottom paragraphPubMed ID5288752
|"[Researchers] conclude that losses of translational plus rotational entropy of 40-50 e.u. are to be expected for many bimolecular reactions in solution, in view of the small dependence of these quantities on molecular size (table 1), and that this loss will be compensated to a variable extent by low-frequency motions in the product or transition state."