Mean lifetime of mRNA

Range ~5 minutes
Organism bacteria
Reference Bakshi S, Siryaporn A, Goulian M, Weisshaar JC. Superresolution imaging of ribosomes and RNA polymerase in live Escherichia coli cells. Mol Microbiol. 2012 Jul85(1):21-38. doi: 10.1111/j.1365-2958.2012.08081.x. p.22 left column 2nd paragraphPubMed ID22624875
Primary Source Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A. 2002 Jul 23 99(15):9697-702 AND Montero Llopis P, Jackson AF, Sliusarenko O, Surovtsev I, Heinritz J, Emonet T, Jacobs-Wagner C. Spatial organization of the flow of genetic information in bacteria. Nature. 2010 Jul 1 466(7302):77-81. doi: 10.1038/nature09152.PubMed ID12119387, 20562858
Comments "Comparison of the mean lifetime of mRNA (~ 5 min) with the mean time to transcribe a message (~ 20 s) suggests that most translation occurs on complete mRNA copies that have been released from RNAP and diffused to the ribosome-rich regions (primary sources)."
Entered by Uri M
ID 108592