Percent of proteins that are rapidly degraded (with half life of ~1 hour)

Range 2 to 7 %
Organism Bacteria Escherichia coli
Reference Nath K, Koch AL. Protein degradation in Escherichia coli. I. Measurement of rapidly and slowly decaying components. J Biol Chem. 1970 Jun 10 245(11):2889-900. p.2889 left column 2nd paragraphPubMed ID4912536
Method "The rate of degradation of intracellular radioactive protein of bacterial cells supported by a membrane filter has been measured directly from the appearance of radioactivity in the carrier-containing perfusate. For this purpose a perfusion apparatus has been constructed from a microsyringe filter holder."
Comments "Only a limited portion of the cellular protein is subject to rapid degradation. It decays with a half-life of approximately 1 hour and constitutes 2 to 7% of the total cellular protein of cells growing in glucose minimal medium under various nutritional conditions (including growth and starvation). The proportion of the total protein synthesis which is directed to the synthesis of this rapidly degrading protein component increases with decreasing growth rate."
Entered by Uri M
ID 108404