Time for removal of senescent red blood cell

Value 42 Days
Organism Mouse Mus musculus
Reference de Jong K, Emerson RK, Butler J, Bastacky J, Mohandas N, Kuypers FA. Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia. Blood. 2001 Sep 198(5):1577-84PubMed ID11520810
Method Researchers determined the survival times of murine sickle cells in the circulation by labeling the entire RBC cohort with biotin and monitoring the disappearance of the biotinylated cells using streptavidin labeling at several time intervals after biotinylation. Survival curves plotted in Figure 4 show that normal mouse RBC removal was linear, as reported earlier. The number of biotinylated cells decreased approximately 2.5% per day, with 50% surviving at 20 days and complete disappearance of all labeled cells by 42 days, indicating that on average 2.5% of the senescent RBC mass was replaced per day.
Entered by Uri M
ID 104867