Effect of dietary total calories and fat, and body weight on tumor incidence

Range Table - link %
Organism Mouse Mus musculus
Reference Albanes D. Total calories, body weight, and tumor incidence in mice. Cancer Res. 1987 Apr 15 47(8):1987-92. p.1990 table 3PubMed ID3828987
Method Abstract:"The relation between total caloric intake, body weight, and tumorigenesis, as well as the independence of these effects from those of dietary fat, were evaluated using data from 82 published experiments involving several tumor sites in mice." P.1987 right column bottom paragraph:"The quantitative relation between study dietary factor (e.g., total calories) and body weight levels, and tumor incidence was evaluated in these analyses. Multiple linear regression based on least-squares means (weighted by experimental group sample size) was used to estimate cumulative incidence of tumors among the experimental groups for several levels of caloric intake, body weight, and calories and fat. Two methods were used to maintain analytic validity by controlling for intraexperimental factors which might have affected tumor incidence (e.g., strain or carcinogen dosage). In the first, adjustment was made for cumulative tumor incidence in the control groups when calculating incidence in the experimental groups by including this factor in the regression model (Figs. 2 and 3 and Table 3)."
Comments P.1990 left column 2nd paragraph:"Table 3 demonstrates mean experimental dietary levels and tumor incidence (the latter adjusted for control group incidence) for four dietary categories, as defined by the median intakes of fat and calories. The lowest incidence was observed in the two low calorie (and low weight) categories, while the high calorie categories exhibited significantly higher (and equivalent) incidence. Thus, the effect of caloric intake was independent of the level of dietary fat intake. In contrast, no effect (or a small inverse effect) on incidence was observed for the two levels of dietary fat. Greater stratification of fat and calories (e.g., by tertiles) yielded similar results, although based on smaller numbers of experiments in each category." See notes beneath table
Entered by Uri M
ID 112394