Age-adjusted Ki values (and their 95% CIs) of specific metabolic rates of major organs and tissues

Range Table - link kcal/(kg×day)
Organism Human Homo sapiens
Reference Wang Z. et al., Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure. Am J Clin Nutr. 2010 Dec92(6):1369-77. doi: 10.3945/ajcn.2010.29885. p.1375 table 5PubMed ID20962155
Method Abstract 3rd paragraph:"A new approach was developed to evaluate the K(i) [specific metabolic rate] values of major organs and tissues on the basis of a mechanistic model: REE = Σ(K(i) × T(i)), where REE is whole-body resting energy expenditure measured by indirect calorimetry, and T(i) is the mass of individual organs and tissues measured by magnetic resonance imaging. With measured REE and T(i), marginal 95% CIs for K(i) values were calculated by stepwise univariate regression analysis. An existing database of nonobese, healthy adults [n = 131 body mass index (in kg/m²) <30] was divided into 3 age groups: 21-30 y (young, n = 43), 31-50 y (middle-age, n = 51), and > 50 y (n = 37)."
Comments P.1374 right column top paragraph: "According to Equation 7, age-adjusted coefficients were derived: A = 1.008 (P = 0.30) for the young adults, A = 0.996 (P =0.54) for the middle-age adults, and A = 0.969 (P <0.001) for the adults aged >50 y. According to Equation 8, the age-adjusted Ki values (in kcal/(kg×d)) and their 95% CIs were calculated for the >50-y group (Table 5): 194 for liver, 233 for brain, 426 for heart and kidneys, 12.6 for skeletal muscle, 4.4 for adipose tissue, and 11.6 for residual mass." P.1376 left column top paragraph:"For the >50-y group, Elia's Ki values were outside the right boundary of 95% CIs for the 7 organs and tissues (Figure 4). A significantly age-adjusted coefficient, A = 0.969 (P < 0.001), should be applied for this group of adults. On the basis of the predicted age-adjusted coefficient, the age-modified Ki values were suggested (Table 5)."
Entered by Uri M
ID 112385