Possible variation in gene expression according to genomic location

Value 300 fold
Organism Bacteria Escherichia coli
Reference Soler-Bistué A et al., Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity. PLoS Genet. 2015 Apr 13 11(4):e1005156. doi: 10.1371/journal.pgen.1005156. p.2/21 bottom paragraph & p.13/21 top paragraphPubMed ID25875621
Primary Source [8] Block DH, Hussein R, Liang LW, Lim HN. Regulatory consequences of gene translocation in bacteria. Nucleic acids research. 2012 40(18):8979–92. Epub 2012/07/27. doi: 10.1093/nar/gks694 PubMed Central PMCID: PMCPMC3467084. [25] Bryant JA, Sellars LE, Busby SJ, Lee DJ. Chromosome position effects on gene expression in Escherichia coli K-12. Nucleic acids research. 2015 42(18):11383–92. doi: 10.1093/nar/gku828PubMed ID22833608, 25209233
Comments P.2/21 bottom paragraph:"Additionally the fact that rRNA are in multiple copies enhances replication-linked gene dosage effect. For example, Escherichia coli bears 7 rRNA copies, therefore in exponential phase their copy number can go from 7 to 28 while RP [ribosomal protein] and RNAP which are in single copy can go from 1 to as most 4 copies. On the other hand, gene expression can vary by 300-fold according to its genomic location, an amount that is not explained by gene dosage effects but rather by the presence of overlapping chromosome structural organization features [primary sources 8, 25]." P.13/21 top paragraph:"A recent publication reported 300-fold expression changes of gfp according to its genomic site of insertion in slow growing conditions [primary source 25]. Such variation in expression cannot be accounted by gene dosage effects but rather the presence of overlapping chromosome structural organization features."
Entered by Uri M
ID 112366