Reaction sequence and timing of synaptic transmission

Range Figure - link
Organism Rat Rattus norvegicus
Reference Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci. 2004 27: 509-47. p.513 figure 2PubMed ID15217342
Primary Source Meinrenken CJ, Borst JG, Sakmann B. 2003. Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held. J. Physiol. 547: 665–89PubMed ID12562955
Comments "The size of the calyx allows direct electrophysiological recordings from a terminal, making it possible to monitor pre- and postsynaptic events simultaneously (Figure 2). Major advances in [researchers'] understanding of neurotransmitter release were made in the calyx of Held by relating the precise concentration and dynamics of Ca2+ to synaptic vesicle exocytosis (reviewed in Schneggenburger et al. 2002, and in primary source). When an action potential invades the calyx terminal, the Ca2+ current begins at the peak of the action potential and ends before the calyx terminal is fully repolarized (Figure 2: Helmchen et al. 1997)."
Entered by Uri M
ID 111281