Number of elongation factor Tu (EF-Tu) per ribosome (most abundant protein in fast-growing)

Range 6 - 7 molecules/ribosome
Organism Bacteria Escherichia coli
Reference Klumpp S, Scott M, Pedersen S, Hwa T. Molecular crowding limits translation and cell growth. Proc Natl Acad Sci U S A. 2013 Oct 15 110(42):16754-9. doi: 10.1073/pnas.1310377110. p.16754 left column bottom paragraphPubMed ID24082144
Primary Source Neidhardt FC, Bloch PL, Pedersen S, Reeh S (1977) Chemical measurement of steadystate levels of ten aminoacyl-transfer ribonucleic acid synthetases in Escherichia coli. J Bacteriol 129: 378–387.PubMed ID318645
Comments "In addition to their high ribosome content, rapidly growing bacteria also contain large amounts of other proteins associated with translation. In particular, the most abundant protein in fastgrowing E. coli is elongation factor Tu (EF-Tu), with about six to seven molecules per ribosome (primary source), and accounting for up to 10% of the total protein mass under conditions of rapid growth (refs 2, 16 BNID 106415)."
Entered by Uri M
ID 110048