Number of different polypeptides found to be present in significantly similar normalized copy numbers

Range ≥1,500 Different polypeptides/cell
Organism Human Homo sapiens
Reference Finka A, Goloubinoff P. Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis. Cell Stress Chaperones. 2013 Feb 21 p.4 right column top paragraphPubMed ID23430704
Method Intensity-based absolute quantification (iBAQ)
Comments In 11 different cell types. "The study performed normalization of protein levels based on a relatively low total protein abundance value of about 60 mg/ml. Commonly found values are often 3 fold higher and thus might change the estimates of the paper accordingly." "various types of human cells likely express at least 1,500 proteins in constant proportions, most of which likely carrying essential housekeeping functions."
Entered by Uri M
ID 109390