Rate constant of acetylcholinesterase (ACHE)

Value 16000 Sec^-1
Organism Unspecified
Reference Monika Fuxreiter and Arieh Warshel, Origin of the Catalytic Power of Acetylcholinesterase:? Computer Simulation Studies, J. Am. Chem. Soc., 1998, 120 (1), pp 183–194 DOI: 10.1021/ja972326m p.183 left column top paragraph
Primary Source Rosenberry TL. Acetylcholinesterase. Adv Enzymol Relat Areas Mol Biol. 1975 43: 103-218.PubMed ID891
Comments "Acetylcholinesterase (ACHE) is a serine hydrolaze that terminates the impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine. To accomplish this task the enzyme uses one of the highest rate constants known (primary source) (kcat=1.6?10^4s-1)." See BNID 104100
Entered by Uri M
ID 109216