Amount of acetylcholine (ACh) released per presynaptic nerve stimulation at the neuromuscular junction

Value 1E-15 mmoles
Organism Unspecified
Reference Scimemi A, Beato M. Determining the neurotransmitter concentration profile at active synapses. Mol Neurobiol. 2009 Dec40(3):289-306. p.290 left column bottom paragraphPubMed ID19844813
Primary Source Acheson GH. Physiology of neuro-muscular junctions chemical aspects. Fed Proc. 1948 Sep7(3):447-57.PubMed ID18886070
Method This value was inferred from titration experiments through exogenous ACh applications which, however, reproduced only roughly the time course of miniature end-plate potentials (mEPPs).
Comments Iontophoresis approaches proposed a tenfold increase in the above value (10^-14 mmoles [Krnjevic et al., 1958 PMID 13590121])
Entered by Uri M
ID 107298