| Comments |
The slope of
0.8 kcal/mol per CH2 group is similar to
that observed by Tanford (ref 17) for the partitioning
of the neutral form of a fatty
acid from water into a bulk alkane
phase. Myristoylated
glycine (myr-G) myr-GA,
myrGAA and a myristoylated peptide
corresponding to the first 15 residues of
Src (see Fig. 1) all bind with a unitary
Gibbs free energy of ?Gu=-8 kcal/mol into the hydrocarbon interior
of the membrane
to electrically neutral vesicles. This
implies that about 8/0.8 = 10 CH2 groups
are removed from water and embedded into the hydrocarbon interior
of the membrane. |