Diffusion coefficient of transcription factors in the nucleus

Range 0.5-5 μm^2/sec
Organism Eukaryotes
Reference Hager GL, McNally JG, Misteli T. Transcription dynamics. Mol Cell. 2009 Sep 24 35(6):741-53.PubMed ID19782025
Primary Source Gorski SA, Dundr M, Misteli T. The road much traveled: trafficking in the cell nucleus. Curr Opin Cell Biol. 2006 Jun18(3):284-90PubMed ID16621498
Comments TF motion is not directional and does not require energy. Measured diffusion coefficients values (range above) depend on a molecule's shape, size, and its interactions with chromatin.
Entered by Uri M
ID 105295