Apparent Ki (inhibition constant) of isocitrate dehydrogenase kinase in presence of isocitrate

Range 15-60 µM
Organism Bacteria Escherichia coli
Reference E.M.T. El-Man, H.G. Nimmo and W-H. Helms, The role of isocitrate in control of the phosphorylation of isocitrate dehydrogenase in Escherichia coli ML308, FEBS 2456 April 1985 Volume 183, number 2 p.254 right column 3rd paragraph
Primary Source Nimmo GA, Nimmo HG. The regulatory properties of isocitrate dehydrogenase kinase and isocitrate dehydrogenase phosphatase from Escherichia coli ML308 and the roles of these activities in the control of isocitrate dehydrogenase. Eur J Biochem. 1984 Jun 1 141(2):409-14.PubMed ID6329757
Comments Isocitrate activates isocitrate dehydrogenase phosphatase at concentrations in the range O-5 mM DL-isocitrate.
Entered by Uri M
ID 105253