||Lynch M, Sung W, Morris K, Coffey N, Landry CR, Dopman EB, Dickinson WJ, Okamoto K, Kulkarni S, Hartl DL, Thomas WK. A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A. 2008 Jul 8105(27):9272-7. Table 3PubMed ID18583475
||Analyses are based on an examination of parallel MA lines of a key model system, the yeast Saccharomyces cerevisiae. The initially isogenic lines were passed through 200 single-cell bottlenecks on a 3- to 4-day cycle of clonal growth for a total of ˜4,800 cell divisions per line. Spontaneous mutations in yeast were accumulated in 32 independent sets of haploid lines, 8 in each of four series, A–D, all initiated from the same clonal parent derived from a single laboratory stock, FY10 (leu2?1, ura3–52, MATa)
||The 0.58:1 ratio of indel to base-substitution mutations in the mitochondrial genome of budding yeast is essentially the same as the ratio of 0.62:1 previously observed with MA lines of C. elegans (ref 5 in article).