Percent of polyadenylation sites containing the core motif AAUAAA
| Value | 70 % |
|---|---|
| Organism | Human Homo sapiens |
| Reference | Tian B, Hu J, Zhang H, Lutz CS. A large-scale analysis of mRNA polyadenylation of human and mouse genes. Nucleic Acids Res. 2005 Jan 1233(1):201-12. p.202 right column top paragraphPubMed ID15647503 |
| Comments | The terminal sequence of most mammalian genes contains the consensus AAUAAA hexamer (or a close variant). "Several studies on polyadenylation signal (PAS) suggested that while most human polyadenylation sites contain the canonical AAUAAA (70%), a large portion of genes have single-nucleotide variants, with AUUAAA as the most common one (16,19,20)." |
| Entered by | Uri M |
| ID | 103253 |