Growth rates at which the onset of fermentation typically occurs

Range 0.3 – 0.5 hours^-1
Organism Bacteria Escherichia coli
Reference Szenk M, Dill KA, de Graff AMR. Why Do Fast-Growing Bacteria Enter Overflow Metabolism? Testing the Membrane Real Estate Hypothesis. Cell Syst. 2017 Aug 235(2):95-104. doi: 10.1016/j.cels.2017.06.005. p.99 left column 3rd paragraphPubMed ID28755958
Primary Source Valgepea K, Adamberg K, Vilu R. Decrease of energy spilling in Escherichia coli continuous cultures with rising specific growth rate and carbon wasting. BMC Syst Biol. 2011 Jul 55:106. doi: 10.1186/1752-0509-5-106 AND Ishii N et al., Multiple high-throughput analyses monitor the response of E. coli to perturbations. Science. 2007 Apr 27 316(5824):593-7 DOI 10.1126/science.1132067 AND Vemuri GN, Altman E, Sangurdekar DP, Khodursky AB, Eiteman MA. Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio. Appl Environ Microbiol. 2006 May72(5):3653-61 DOI: 10.1128/AEM.72.5.3653-3661.2006PubMed ID21726468, 17379776, 16672514
Comments P.99 left column 3rd paragraph: "Figure 2 shows a key test of the membrane real estate hypothesis. In E. coli, the onset of fermentation typically occurs at growth rates of 0.3–0.5 hr^-1 (primary sources). But why? [investigators’] calculation of the minimal amount of electron transport chain needed to fuel growth, summarized in Equation 2 and shown by the red line in Figure 2A, demonstrates how rapidly the electron transport chain’s membrane requirements increase with growth rate, eventually becoming untenable."
Entered by Uri M
ID 114706