Annual expansion of the ventricles in healthy elderly and Alzheimer’s disease (AD) patients

Range healthy elderly ~1.5-3.0%: AD patients 5-16% %
Organism Human Homo sapiens
Reference Streitbürger DP et al., Investigating structural brain changes of dehydration using voxel-based morphometry. PLoS One. 2012 7(8):e44195. doi: 10.1371/journal.pone.0044195 p.1 left column top paragraph & p.7 right column 4th paragraphPubMed ID22952926
Primary Source [8] Frisoni GB et al., The clinical use of structural MRI in Alzheimer disease. Nat Rev Neurol. 2010 Feb6(2):67-77. doi: 10.1038/nrneurol.2009.215PubMed ID20139996
Comments P.1 left column top paragraph: "A number of recent studies employing structural magnetic resonance imaging (MRI) have aimed to investigate gray matter (GM), white matter (WM), and the cerebrospinal fluid (CSF) system and its explanatory power for neurodegenerative disorders [refs 1–3]. Regarding Alzheimer’s disease (AD), decreased GM and WM volumes were consistently found [refs 4-5], which are assumed to be related to the loss of neurons and synapses. This, in turn, could also be a plausible explanation for an accompanied increase of CSF as several studies showed an enlarged size of the ventricles due to brain atrophy compared to healthy controls [refs 2, 6, 7]. Annual expansion of the ventricles in healthy elderly and AD patients is around 1.5–3.0% and 5–16%, respectively [primary source]."
Entered by Uri M
ID 114372