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P.1 left column top paragraph: "A number of recent studies employing structural magnetic resonance imaging (MRI) have aimed to investigate gray matter (GM), white matter (WM), and the cerebrospinal fluid (CSF) system and its explanatory power for neurodegenerative disorders [refs 1–3]. Regarding Alzheimer’s disease (AD), decreased GM and WM volumes were consistently found [refs 4-5], which are assumed to be related to the loss of neurons and synapses. This, in turn, could also be a plausible explanation for an accompanied increase of CSF as several studies showed an enlarged size of the ventricles due to brain atrophy compared to healthy controls [refs 2, 6, 7]. Annual expansion of the ventricles in healthy elderly and AD patients is around 1.5–3.0% and 5–16%, respectively [primary source]." |