Membrane curvature in cross section of tubules

Range <100 nm
Organism Eukaryotes
Reference West M, Zurek N, Hoenger A, Voeltz GK. A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature. J Cell Biol. 2011 Apr 18 193(2):333-46. doi: 10.1083/jcb.201011039 p.333 left column top paragraphPubMed ID21502358
Primary Source Staehelin LA. The plant ER: a dynamic organelle composed of a large number of discrete functional domains. Plant J. 1997 Jun11(6):1151-65 AND Prinz WA et al., Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae. J Cell Biol. 2000 Aug 7 150(3):461-74 AND Hu J et al., Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science. 2008 Feb 29319(5867):1247-50. doi: 10.1126/science.1153634PubMed ID9225461, 10931860, 18309084
Comments P.333 left column top paragraph: "In all eukaryotes, the peripheral ER (endoplasmic reticulum) branches out of the nuclear envelope (NE) as a membrane network of interconnected tubules and cisternae with a single lumen (Estrada de Martin et al., 2005a, English et al., 2009). The ER has an elaborate and conserved shape, and yet, little is known about how ER domains are shaped and distributed by membrane proteins. The ER domains that are most obvious by fluorescence microscopy are peripheral ER cisternae and tubules. The cisternal regions consist of relatively flat parallel membrane bilayers separated by a lumen and have low membrane curvature. The cisternae are interconnected with the rest of the ER network, which can be mostly tubular in shape. In contrast to cisternae, tubules have high membrane curvature in cross section with reported diameters of <100 nm (primary sources)."
Entered by Uri M
ID 113954