Normal plasma norepinephrine and epinephrine concentrations

Range Table - link pg/ml
Organism Human Homo sapiens
Reference Cryer PE. Isotope-derivative measurements of plasma norepinephrine and epinephrine in man. Diabetes. 1976 Nov25(11):1071-82. p.1072 table 1PubMed ID825406
Primary Source [2] Engelman K, Portnoy B. A sensitive double-isotope derivative assay for norepinephrine and epinephrine. Normal resting human plasma levels. Circ Res. 1970 Jan26(1):53-7. [11] Pedersen EB, Christensen NJ. Catecholamines in plasma and urine in patients with essential hypertension determined by double-isotope derivative techniques. Acta Med Scand. 1975 Nov198(5):373-7.PubMed ID4903077, 1199813
Method P.1071 right column 2nd paragraph: "The double-isotope-derivative method for the measurement of catecholamines provided, in addition to specificity, improved sensitivity over that of available fluorometric methods. However, it was not optimally sensitive and required preextraction and concentration of the catecholamines from relatively large volumes of plasma. In addition, some lack of precision at low physiologic catecholamine concentrations was acknowledged [primary source 2]."
Comments P.1072 right column bottom paragraph: "Plasma norepinephrine and epinephrine concentrations in normal subjects, measured in the laboratories of Engelman (primary source 2) and of Christensen (primary source 11) with the double-isotope-derivative method and in [investigators’] laboratory with the single-isotope modification, are shown in table 1. The normal values from these and from other laboratories (primary sources 7, 12-15) are remarkably similar. Although DeQuattro and Chan (primary source 12) observed higher total plasma catecholamine concentrations in women than in men, most investigators have not found a sex difference in plasma norepinephrine or epinephrine concentrations (table 1)."
Entered by Uri M
ID 113137