||P.5 right column bottom paragraph: "During spreading of fibroblasts, membrane area is observed to
increase by 80% with the doubling of the cell area in contact
with the substrate, and other cell types show similar trends
although less dramatic [BNID 112510]. Membrane tensions of unspread and spread cells as measured by tether pulling are identical. Without addition of membrane, a lipid bilayer will rupture upon a 3–5% increase in area, due to excessive membrane tension [primary source]. Something therefore must compensate for the large changes in cell and membrane area required for a
cell to spread once membrane folds have been pulled out."