Mean percentage of different bacterial groups within the mucosal biofilm

Range Table - link
Organism Human Homo sapiens
Reference Swidsinski A, Weber J, Loening-Baucke V, Hale LP, Lochs H. Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease. J Clin Microbiol. 2005 Jul43(7):3380-9. p.3384 table 5PubMed ID16000463
Method P.3380 right column bottom paragraph:"Fluorescence in situ hybridization (FISH) combines the molecular identification of bacteria with the direct visualization of the relationships between the bacteria and the mucosa, providing a significant advantage over culture, PCR, and histological methods alone. In this study, the composition and spatial organization of the mucosal bacteria in patients with IBD [inflammatory bowel disease] and controls were investigated by FISH with a broad range of bacterial group-specific rRNA-targeted probes."
Comments P.3383 left column:"Disease-related differences in occurrence and composition of the mucosal flora: Bacteroides was dominant in biopsy specimens from IBD patients, especially in patients with Crohn's disease. Bacteria that hybridized with the Bac-Bfra probe represented up to 80% of all mucosal bacteria in some IBD patients. In contrast, the mean prevalence of Bacteroides spp. was lower than 15% in patients with IBS [irritable bowel syndrome]. The biofilm in patients with IBS was mainly composed of bacteria that hybridized with the Erec probe (Table 5 Fig. 2). In some IBS patients, bacteria that hybridized with the Erec probe represented up to 90% of all bacteria that positively hybridized with the universal Eub338 probe." CD=Crohn’s disease: UC=Ulcerative colitis: slc=self-limiting colitis. See notes beneath table
Entered by Uri M
ID 112362