Fraction of genes showing rhythmic mRNA accumulation

Range ~10 %
Organism Unspecified
Reference Mauvoisin D et al., Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver. Proc Natl Acad Sci U S A. 2014 Jan 7 111(1):167-72. doi: 10.1073/pnas.1314066111. p.167 left column 3rd paragraphPubMed ID24344304
Primary Source [4] Doherty CJ, Kay SA (2010) Circadian control of global gene expression patterns. Annu Rev Genet 44(1):419–444. doi: 10.1146/annurev-genet-102209-163432.PubMed ID20809800
Comments p.167 left column 3rd paragraph:"In mammals, the molecular oscillator uses interconnected transcriptional and translational feedback loops, in which multiple layers of control, including temporal posttranscriptional and posttranslational regulation, play important roles (ref 3). An active area of chronobiology aims at understanding how the temporal signals from the core oscillator are relayed to clock output function. In this context, genome-wide rhythms in mRNA accumulation were characterized in several models. In general, around 10% of the genes, encoding many enzymes involved in different aspects of cellular metabolism, show rhythmic mRNA accumulation, establishing the role of the circadian clock in temporally gating rhythmic physiology (primary source)."
Entered by Uri M
ID 111860