Total thymocytes at birth

Range ≥5×10^10 cells
Organism Human Homo sapiens
Reference Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu Rev Immunol. 2000 18: 529-60. DOI: 10.1146/annurev.immunol.18.1.529 p.547 2nd paragraphPubMed ID10837068
Primary Source Westerman J, Pabst R. 1992. Distribution of lymphocyte subsets and natural killer cells in the human. Clin. lnvest. 70: 539– 544PubMed ID1392422
Comments p.547 2nd paragraph:"If [investigators] assume that human thymic output is maximal at birth and comparable to the level of thymic export in mice (~2% of total thymocytes exported per day) (ref 103 BNID 102647), and that total thymocytes at birth are = 50 × 10^9 (primary source), then thymic output per day in normal newborn subjects will be = 10^9 new naive T cells."
Entered by Uri M
ID 111616