Fraction of enzymes containing at least two channels 15Å long

Range ≥64.2 %
Organism Various
Reference Pravda L et al., Anatomy of enzyme channels. BMC Bioinformatics. 2014 Nov 18 15(1):379. doi: 10.1186/s12859-014-0379-x. abstract, p.2 left column 2nd & 3rd paragraphs, p.5 right column bottom paragraph & p.6 left column bottom paragraphPubMed ID25403510
Method p.2 left column 2nd paragraph:"Despite a large effort, and recent progress in the field, an in-depth analysis of enzyme channels is lacking. Here, [investigators] use an advanced software tool, MOLE 2.0, developed for analysis of biomacromolecular channels [ref 30], to survey 4,306 enzymes annotated in the Catalytic Site Atlas (CSA). [They] identify that more than 64% of enzyme structures contain channels at least 15 Å long from the active site."
Comments p.5 right column bottom paragraph:"Long channels (>15 Å) are a common feature of enzymes, with over 64% containing at least two such channels. This shows that the majority of enzymes have buried active sites accessible via a network of access channels. Hence there is an apparent tendency for enzymes to bury their active site, i.e., to limit and control direct connection of active sites with the surrounding environment." p.6 left column bottom paragraph:"To conclude, [investigators] analyzed channels in 4,306 enzyme structures annotated in the Catalytic Site Atlas. [They] identified that at least 64% of enzyme structures contain on average two channels longer than 15 Å leading to the catalytic site."
Entered by Uri M
ID 111519