RNA Pol II half life in ES [Embryonic Stem] cells

Value 6.9 min
Organism Mouse Mus musculus
Reference Jonkers I, Kwak H, Lis JT. Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons. Elife. 2014 Apr 29 3: e02407. doi: 10.7554/eLife.02407. p.7 top paragraph & p.14 bottom paragraphPubMed ID24843027
Comments "The mean half-life of Pol II is 6.9 min, in agreement with the decay rates measured in Drosophila (Henriques et al., 2013 Buckley et al., 2014). Thus, promoter proximal Pol II stability is comparable between species and paused Pol II is relatively stable...[researchers] find that the average half-life of paused Pol II is 7 min, indicating that Pol II pausing is remarkably stable, and not the consequence of fast, repeated rounds of initiation and termination."
Entered by Uri M
ID 111272