Base-substitution rates estimated from evolution experiments with whole-genome data

Range Table - link
Organism bacteria
Reference Wielgoss S. et al., Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli. G3 (Bethesda). 2011 Aug 1 1(3):183-186. p.185 table 2PubMed ID22207905
Primary Source See refs beneath table
Method (Abstract:) "[Researchers] sequenced 19 Escherichia coli genomes from a 40,000-generation evolution experiment and directly inferred the point-mutation rate based on the accumulation of synonymous substitutions. The resulting estimate was 8.9 × 10^-11 per base-pair per generation, and there was a significant bias toward increased AT-content. [They] also compared [their] results with published genome sequence datasets for other bacterial evolution experiments."
Comments "To put [researchers'] estimate into context, [they] performed a similar analysis of all other published whole-genome datasets for bacterial evolution experiments with known numbers of generations (Table 2). Taking the other experiments together, [they] found 10 synonymous SNPs in 18 independently evolved (nonmutator) clones in a total of 30,550 generations. These other datasets combined thus provide only ~10% of the power, in terms of cumulative generations, as the long-term dataset that [they] have generated and analyzed. As a consequence, the estimated point-mutation rates for these other experimental systems are subject to much greater statistical uncertainty." See notes beneath table
Entered by Uri M
ID 111229