| Range |
actin monomers 4462 s^-1, Arp2/3 complex 70 s^-1, capping protein 60 s^-1, cofilin 510 s^-1 sec^-1
|
| Organism |
Fission yeast Schizosaccharomyces pombe |
| Reference |
Berro J, Sirotkin V, Pollard TD. Mathematical modeling of endocytic actin patch kinetics in fission yeast: disassembly requires release of actin filament fragments. Mol Biol Cell. 2010 Aug 15 21(16):2905-15. doi: 10.1091/mbc.E10-06-0494. p.2912 right columnPubMed ID20587776
|
| Comments |
"[Researchers'] model does not take into account the geometry of the
actin network around the patch, but the actin filament network
might influence diffusion of the reactants and limit the
rates of the reactions. However, the following calculations
show that diffusion of small proteins does not limit actin
patch assembly. [Researchers] estimate from [their] simulations that proteins
from the cytoplasm are consumed at the maximum
following rates: actin monomers 4462 s^-1, Arp2/3 complex
70 s^-1, capping protein 60 s^-1, and cofilin 510 s^-1." |
| Entered by |
Uri M |
| ID |
111096 |