| Range |
>50 %
|
| Organism |
Human Homo sapiens |
| Reference |
Altman BJ, Dang CV. Normal and cancer cell metabolism: lymphocytes and lymphoma. FEBS J. 2012 Aug279(15):2598-609. doi: 10.1111/j.1742-4658.2012.08651.x. p.2601 right column bottom paragraphPubMed ID22672505
|
| Primary Source |
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT & Aster JC (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269–271.PubMed ID15472075
|
| Comments |
"Cancer cells mimic the activated state of lymphocytes
by expressing mutated forms of growth factor
receptors or other components of the receptor signaling
pathways. For instance, the Notch pathway is critical
in early B-cell and T-cell development and lineage
selection [ref 60], and, not coincidentally, is mutated in
> 50% of T-cell acute lymphoblastic leukemias [primary source]." |
| Entered by |
Uri M |
| ID |
110713 |