Time for mRNA or mRNP to reach the nuclear periphery in typical mammalian cell nucleus (7μm diameter)

Range 2 - 6 min
Organism Mammals
Reference Oeffinger M, Zenklusen D. To the pore and through the pore: a story of mRNA export kinetics. Biochim Biophys Acta. 2012 Jun1819(6):494-506. doi: 10.1016/j.bbagrm.2012.02.011. p.497 right column 2nd paragraphPubMed ID22387213
Primary Source J. Braga, J. Rino, M. Carmo-Fonseca, Photobleaching microscopy reveals the dynamics of mRNA-binding proteins inside live cell nuclei, Prog. Mol. Subcell. Biol. 35 (2004) 119–134.PubMed ID15113082
Comments "So how long does it take an mRNA (or mRNP) to reach the nuclear periphery? Considering that mRNAs move by Brownian motion, the transit time of an mRNP across a typical mammalian cell nucleus (7 µm in diameter) was calculated to be in the range of 2–6 min [primary source]." mRNP="Messenger RNP (messenger ribonucleoprotein)=mRNA with bound proteins. (wiki)"
Entered by Uri M
ID 110668