| Value |
600
Å^2
|
| Organism |
Unspecified |
| Reference |
Alan S. Perelson, Ge´rard Weisbuch, Immunology for physicists, Rev. Mod. Phys. 69, 1219–1268 (1997) p.1222 right column top paragraph |
| Primary Source |
Amit AG, Mariuzza RA, Phillips SE, Poljak RJ. Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution. Science. 1986 Aug 15 233(4765):747-53.& Ajitkumar P et al., Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell. 1988 Jul 1 54(1):47-56.PubMed ID2426778, 3260136
|
| Comments |
"Recognition in the immune system occurs at the molecular level and is based on the
complementarity in shape between the binding site of
the receptor and a portion of the antigen called an
epitope (see Fig. 2). The interaction between the receptor and the epitope is noncovalent and usually involves
van der Waals forces, interactions among charged
groups, and hydrogen bonds. These weak interactions
are nevertheless strong enough to keep the macromolecules
bound when the area of interaction is sufficiently
large. Typical areas of interaction are 600 Å^2 (primary sources)." |
| Entered by |
Uri M |
| ID |
109929 |