Catalytic rate of peptide bond cleavage by Lon and Clp with various substrates

Range Table - link
Organism Bacteria Escherichia coli
Reference Maurizi MR. Proteases and protein degradation in Escherichia coli. Experientia. 1992 Feb 15 48(2):178-201. p.187 table 3PubMed ID1740190
Method See note beneath table
Comments "With many protein substrates, degradation by Lon requires the continuous hydrolysis of ATP. However, cleavage of smaller proteins, such as oxidized insulin B chain, and fluorogenic peptides proceeds quite readily in the presence of non-hydrolyzable analogs, such as AMPPNP (table 3)"
Entered by Uri M
ID 109927