Highest glucose uptake rate that still allows the maximal NADH formation rate

Value 2.4 mmol/(gCDWхh)
Organism Bacteria Escherichia coli
Reference Blank LM, Ebert BE, Bühler B, Schmid A. Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint-based modeling and experimental verification. Biotechnol Bioeng. 2008 Aug 15 100(6):1050-65. doi: 10.1002/bit.21837. p.1055 right column top paragraphPubMed ID18553399
Method "In order to define maximal net NADH formation rates in E. coli, which can serve as target values for redox cofactordependent biocatalysis, [researchers] investigated the capability of the E. coli metabolic network to regenerate the reduced cofactor NADH during glucose catabolism by FBA using a stoichiometric model of central carbon metabolism."
Comments "The highest glucose uptake rate still allowing the maximal NADH yield on glucose (2.4mmol/(gCDW?h) for E. coli) can be considered as optimal and results in a theoretical NADH formation rate of 22mmol/(gCDW?h)."
Entered by Uri M
ID 109673