Aneuploidy rate

Range 2 to 10 sperm: 20 to 30 oocytes %
Organism Human Homo sapiens
Reference Jianbin Wang, H. Christina Fan, Barry Behr and Stephen R. Quake Genome-wide Single-Cell Analysis of Recombination Activity and De Novo Mutation Rates in Human Sperm, Cell 150, 402–412, July 20, 2012 p.408 right column top paragraphPubMed ID22817899
Method Researchers collected a sperm sample from a 40-year-old Caucasian individual (P0) whose genome has been sequenced (Pushkarev et al., 2009), clinically annotated (Ashley et al., 2010), and haplotype phased (Fan et al., 2011).
Comments Although the aneuploidy rate for oocytes (20%–30%) is higher than that found in sperm (2%– 10%), male genome defects are still a significant contribution to conception failure.
Entered by Uri M
ID 108037